Abstract: The middle eastern Aegean depression is formed by vertical displacements along the NB- to N-trending structural planes inherited from pre-Neogene time. On the west - east the depression is bounded by Karaburun-Midilli Menderes structural highs, respectively. From west to east it is divided in Foça depression, Yamanlar high, Akhisar depression, which constitute individual assemblages of tectonic-stratigraphic segments. Thefill of the middle eastern Aegean depression is composed of successively reoccuring sediments volcanic products.The rock units are mostly separated by erosional planes exhibit overlap  onlap relationships on boundingstructural highs. The thickest lower portion of the Neogene succession is restricted to the Foça depression; theuppermost portion occupies both the Foça, Akhisar depressions.  During the Neogene, the NE- to N-trending structural-stratigraphic segments have been fragmented by NW- toWNW-trending faults. Both NE- to N-, NW- to WNW-trending structural lines were continuously acted ashinges. WNW- to W-trending structural features are lately formed characterized by southward tilted fault-blocks.Their E-W extensions are limted by NE- to N-trending structures.The absence of gradation between the NE- to N-trending (Miocene-Pliocene), NW- to WNW-trending (MiocenePliocene) WNW- to W-trending (?Pliocene-Quaternary) structural-stratigraphic systems suggest the different driving tectonic forces. The middle eastern Aegean depression seems to be a particular rift system with major linearityof NE-N direction. In the Quaternary surficial aqueous deposition, contemporary deformation, structural morphological evolution have been controlled affected by hinge lines inherited from Neogene. To geophysical criteriathe depression preserves its characteristics of rift structure.