Abstract: In this study, to investigate the relationship between ore genesis and trace element contents of,pyrites of massive sulphide deposits from Turkey and Cyprus, 42 pyrite samples from 14 deposits are analyzed fortheir titanium, nickel, cobalt, vanadium, selenium, and arsenic contents which are characteristic for pyrites. Thesamples were taken from Pontid type and Cyprus type massive sulphide deposits. The samples used were from,for Pontid type deposits, Lahanos, îsrail, Kızılkaya, Kotarakdere, Madenköy-Çayeli, and Anayatak-JMfurgul; and forCyprus type deposits, Küre (Aşıköy and Bakibaba), Ergani I Anayatak and Weiss), Madenköy-Siirt, Agrokipia, Mavrovouni, and Skouriotissa.Titanium, cobalt, and arsenic contents, cobalt: nickel rations, and to some extent nickel contents appear aspossible discriminators for the two different types of mas sive sulphides. The ranges and means of titanium and cobalt are higher in Cyprus type massive sulphides compared to Pontid type. Arsenic has similar ranges in both types,but it has a higher mean in Pontid type deposits Cobalt: nickel ratios, both ranges and means, display an increasefrom Pontid type towards Cyprus type massive sulphides- The ranges and the means of nickel contents are slightlyhigher in Cyprus type compared to Pontid type. Neither the ranges nor the means of vanadium and selenium contents appear to be useful for distinguishing the two types of massive sulphides.