Abstract: Most of the antique cities in Western and Southwestern Anatolia were established along the active faultzones. The Myra Ancient City, located in the region between the Fethiye-Burdur Fault Zone and the Pliny-Strabotrenches in southwest Anatolia, is situated on the NE-SW trending active normal faults. According to archeologicalevidence, Ancient City of Myra was affected by historical earthquakes. Analysis of the damaged relics indicates: (i)Nearly all relics of the Myra Ancient City show different degrees of earthquake related damage and these damagesmay be evidence for 141 A.D., 240 A.D., 344 A.D. earthquakes in the Holocene time interval; (ii) The nekropolisof Myra, amphitheatre and the port of Myra were ruptured as a systematically collapsed columns, collapsed walls,and by rotated and displaced blocks in the damage zone; (iii) NE-SW trending damage zone linked with Kale Faultand Kekova Fault and NW–SE-directed extension is mainly responsible for the recent faulting along the Kale Fault.