Abstract: The Karaali Geothermal field, one of the geothermal areas in Turkey is located 45 km south-east ofŞanlıurfa province in southeastern Anatolia. It also covers the area including Karaali village within the Akçakale graben. In addition, Karaali geothermal area is of great importance for Şanlıurfa not only because of thermal tourism and being a greenhouse heating source, but also because it is located in the Harran Plain which has very important agricultural potential for the development of Turkey. In recent studies, direct/indirect uncontrolleddischarge of geothermal waters in the nearest drainage channels was shown to adversely affect soil and plantsin terms of heavy metal contamination This study aims to determine the direct and indirect exposure to heavy metalpollution originating in geothermal waters with respect to human health. Seasonal sampling was carried out between February - October 2018 at 6 points in total, including the drainage channels (D9, D10, D11, D12 and D13) in thevicinity of Karaali geothermal fluid (KJ). Heavy metal parameters were measured such as Al, As, Co, Cr, Fe, Mn,Mo, Ni, Pb, Sb, Se and V. As a result, it was concluded that the sampling values exceed the values for Al, Cr, Fe,Mo, Ni, Se and V in the regulations that should be taken in consideration for the reuse of water in the drainagechannels. Additionally, in nearby 2 groundwater wells (K7 and K8), the limit values were exceeded for Al and Feparameters according to TSE 266, EPA and WHO drinking water criteria. Finally, heavy metal pollution in thedrainage channels affected the wells only in terms of Al and Fe. It was also concluded that the indirect exposureimpact due to heavy metal that is carried to soil, plants and groundwater by the re-use of irrigation water is moreserious for human health than direct exposure caused by groundwater consumption However, over a certain periodof time an increase in parameters exceeding the limit values in terms of heavy metal may also occur.