Abstract: Arsenic (As) contamination in water,  especially in groundwater, has led to major health problems. Dueto the recognition that As at low concentrations in potable water causes crucial health effects, As removal methodshave gained significant importance in recent years. In this study, As concentration was monitored in October and March in ten observation wells located in Harran Plain, which has the largest groundwater reserves in the MiddleEast. According to the analyses, there was no well that exceeded the limit for As concentration (10ppb). The results revealed that As concentrations in October were lower than in March. In March, the highest Asconcentration was observed in Yaygılı well with the value of 4.12 ppb. Ozanlar well had the lowest As concentrationwith the value of <0.5 ppb. In October, the highest As concentration was 2.39 ppb in Çamlıdere well. For Çamlıdereand Yaygılı wells, As removal methods (coagulation and flocculation, adsorption, membrane processes, advancedoxidation processes, electrocoagulation, biochar) were investigated and discussed. As a result of the assessment, itwas estimated that the best available As removal method could be biochar application considering its advantages.